Canine parvovirus, also known as parvo or CPV, is a common infection that affects millions of dogs worldwide. Despite vaccination efforts, parvo has been the leading infectious cause of canine mortality for decades, especially among young puppies.

Here we cover why canine parvovirus is so dangerous to puppies and dogs, how pet parents can protect their dogs from a parvo infection, and what treatment options are available. We even cover how the COVID-19 pandemic brought good news for parvo infections rates.  

About Parvo

Canine parvovirus is a highly contagious virus that can cause inflammation in the bone marrow and destruction of certain cells in the small intestine. There is no cure for CPV, but the mortality rate drops from about 90% to 15-30% when infected dogs receive supportive care for their symptoms of parvo.

Symptoms of Parvo and Treatment

The typical clinical signs of a parvo infection are severe bloody diarrhea, vomiting, lack of appetite, severe dehydration, weight loss, lethargy, and fever. A veterinarian (DVM) will monitor an infected dog’s symptoms and provide intravenous fluids to combat dehydration. They may also provide pain relievers, electrolytes, anti-nausea medication, and nutritional support; in more severe cases blood transfusions are sometimes necessary.

A veterinarian can confirm a CPV diagnosis by performing an ELISA antigen test and measuring the dog’s white blood cell count. But even in suspected cases, it’s important that dogs with signs of parvo are cared for in isolation facilities because it is so contagious.

How Parvo Spreads

Parvovirus is spread through direct contact with an infected dog, but there are many indirect ways puppies can get parvo too. Exposure to feces from an infected dog is a common transmission method; parvo can live on feces and soil for more than a year and it’s not uncommon for dogs to eat feces from other dogs. In addition, dogs can ingest parvo – as well as several other diseases – from communal water bowls. Contaminated environments and people also can aid in the spread of parvo, which explains why outbreaks sometimes happen at kennel facilities.

Vulnerable Dogs

Dogs of any age can get parvo, but puppies are the most affected. This can be credited in part to the success of the parvovirus vaccine in adult dogs. Parvovirus affects the long term health of dogs, making them vulnerable to other health issues in adulthood. One study found that puppies that recover from a parvo infection are more likely to have a lifetime of gastrointestinal symptoms compared to those not infected as adult dogs.

The best approach to protecting your puppy from a parvovirus infection is to vaccinate them before they are exposed to the virus. This means keeping them away from dog parks and anywhere that infected dogs, the feces of infected dogs, or unvaccinated dogs may be. Ideally, have guests remove their shoes at the door and wash their hands before interacting with your puppy.

Despite even the strictest measures, some dogs can become infected with parvo despite receiving the vaccine, and this is called ‘vaccine failure’.

Vaccine failures can happen for several reasons:

Timing of the vaccine. If the puppy is too young, their immune system is not mature enough to fully respond to the vaccine. In their first weeks of life before their own immune system has developed, puppies rely on maternal antibodies to protect them from infections. The maternal antibodies temporarily dampen the response from the puppy’s own immune system to the vaccine. Because of this, parvo vaccines come in a series to maximize the chances that the puppies immune system ‘practices’ fighting the vaccine, but puppies may be vulnerable until the series is complete.

The puppy may have an immune system disorder that prevents them from reacting appropriately to the immune challenge of the vaccine. Health is essential to mount an appropriate immune response to a vaccine. Malnutrition, heavy parasite burdens and other illnesses are potential reasons that vaccines fail.

Dog breed can also affect vaccine efficacy. It’s not clear why, but Rottweilers and Doberman Pinschers are two breeds that are more susceptible to parvo vaccine failure.

Improper vaccination protocol. Canine parvovirus vaccine protocols are ever evolving, and it’s still widely discussed in veterinary medicine what the best practices are for delivering the parvo vaccine series to puppies around the world. Typically, a puppy will receive the core vaccine series and then subsequent booster vaccinations every 1-3 years during adulthood. It is possible too that vaccines lose efficacy if they aren’t shipped, stored, or handled appropriately; although this isn’t as much of an issue in the United States as it is for other countries.

There is no cure for canine parvovirus. Traditional treatment of parvo infections focus on supportive care, such as intravenous fluids, antibiotics (esp. Ampicillin), nutritional support, and anti-nausea drugs.

 More recently, fecal microbiota transplants (FMTs) are also being used for puppies with parvo infections with promising success. A fecal microbiota transplant is a procedure where the stool – inclusive of a complete and thriving community of intestinal microbes – from a healthy donor is transferred into the gastrointestinal tract of the recipient.

FMTs can be performed several ways, including by enema in a veterinarian’s office or by oral FMT capsules. Oral capsules, such as the DoggyBiome Gut Restore Supplements, are considered much less invasive, more affordable, and equally effective compared to other FMT procedures.

The Science: Using FMT As Parvo Treatment

A 2018 study published in the Journal of Veterinary Internal Medicine found that puppies with canine parvovirus recovered significantly faster when they received an FMT compared to those that just received standard care.

Remarkably, 61% of the puppies who received an FMT had their diarrhea resolved in less than 48 hours, compared to the less than 5% of puppies who received standard care. While not statistically significant, the study also found that the mortality rate was lower in the puppies who received the FMT (21%) compared to those who received standard care (36%).

 We reached out to Dr. Marcio Costa, the corresponding author on the study who was surprised how quickly most of the dogs receiving FMT resolved their diarrhea.

 “I wasn’t sure what to expect because I have also tried the procedure on horses, but with quite variable results. Our results were more like what we see in humans that resolve diarrhea within 48 hours after FMT. So I have to confess I was very happy to see that we were able to improve the conditions of those patients,” Dr. Costa said.

 Thanks to the work of Dr. Costa and numerous other researchers, the survival rate of parvovirus infections has drastically improved.

 Interestingly, a silver lining of the COVID-19 pandemic involves a decrease in canine parvovirus infections. Researchers in Texas found parvovirus infections significantly decreased during COVID-19-related lockdowns compared to the same months in years passed, suggesting human activity plays a big part in parvovirus infection rates in developed regions.  

• Canine parvovirus is a dangerous infection that predominantly affects puppies around the world
• Effective vaccination is the best preventative treatment; supportive care is the best supportive treatment with FMTs significantly improving recovery time.  
• Parvo has long term consequences to the intestinal health of the dogs that survive the infection.
• AnimalBiome offers affordable FMTs in capsule for dogs that can be used by both veterinarians to treat parvo infections and dog parents to restore the gut health of their pup who may have recovered from a parvo infection.